Membrane fusion lies at the heart of many cell ... creation of a complex of coiled or "zippered" membrane proteins (SNAREs) that draws cell membranes into close proximity is not sufficient to ...

Figure 1: Membrane fusion on the exocytic and endocytic pathways, in five steps. Our understanding of intracellular membrane fusion has largely rested on three approaches: genetic screens for the ...

Enveloped animal viruses deliver their genetic contents into host cells by a fusion reaction between the virus membrane, which is derived from the host-cell membrane during virus budding, and the ...

"The complex recognizes the right vessel, the right place on the cell surface and the right time for the cargo to be ...

The many factors that contribute to how cells communicate and ... Accepter SNARE proteins then form, allowing fusion with another vesicle membrane. How this mechanistically happens has been ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the ...

The researchers transfected HEK cells with an Omicron spike protein expression construct and compared the membrane fusion activity with constructs from variants such as Alpha, Beta and delta in ...

The S protein is a highly glycosylated and ... changes must occur for the S2 subunit to complete the fusion of the virus to the cell membrane. The two components of the S2 subunit that are ...

In Molecular Cell Prof. Li Dong's group from the ... pathway in which aberrant phase separation of a fusion protein drives ER membrane remodeling and nuclear signaling. The findings not only ...

Membrane fusion and budding mediate fundamental biological processes ... to visualize in real-time the membrane transformations of exo- and endocytosis in live cells (neuroendocrine chromaffin cells).

For this pathway, two membrane proteins play an important role ... In transfected Arabidopsis protoplasts (plant cells without cell walls), green-fluorescent fusion proteins of GPT1 (GPT1-GFP, top) ...

Many viruses, including that perennial winter affliction, the influenza virus, are protected by a lipid membrane on loan from the host cell. The fusion proteins on the surface of the membrane are ...