The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite drug that is widely used for the treatment of cancer, particularly for colorectal cancer. 5-FU exerts its anticancer effects through ...

How does topical fluorouracil work (mechanism of action)? Topical fluorouracil interferes with the ability of cells to grow and divide. The medicine causes cell death, especially among cells that ...

Usually, 5-fluorouracil is given in combination with ... "Textbooks implicate the DNA effects of the drug as the mechanism in all cancer types, but our data shows that RNA damage is what's really ...

Usually, 5-fluorouracil is given in combination with ... Textbooks implicate the DNA effects of the drug as the mechanism in all cancer types, but our data shows that RNA damage is what's really ...

Usually, 5-fluorouracil is given in combination with ... "Textbooks implicate the DNA effects of the drug as the mechanism in ...

TYMS expression levels have been considered as predictive biomarkers for 5-fluorouracil (5-FU) efficacy, although results to date remain controversial. We hypothesized that microRNAs (miRNAs) might ...

"Topical fluorouracil causes epidermal [outer skin layer] injury, which stimulates wound healing and dermal remodeling resulting in improved appearance," the authors write. "The mechanism of ...

This observation suggests that the primary mechanism of bevacizumab is the ... These results suggest that bevacizumab plus fluorouracil-based chemotherapy should be considered a new option for ...