In 2 separate studies, ezetimibe/simvastatin lowered C-reactive protein, LDL cholesterol, and apolipoprotein B levels more than simvastatin or atorvastatin alone.

CRP levels were also further reduced with the combination therapy, a reduction of 46% with rosuvastatin and ezetimibe vs a 28.6% reduction with rosuvastatin alone. EXPLORER: Patients achieving ...

Patients in the bempedoic acid/ezetimibe group had a decrease in LDL of 36.2% vs. an increase of 1.8% in the placebo group, a decrease of 23.2% in the ezetimibe group and a decrease of 17.2% in ...

Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low ... The differences between the two groups in reductions in levels of triglycerides and C-reactive protein were 6.6% and 25 ...

Of the new onset DM cases, 50.9% occurred in the VYTORIN (ezetimibe and simvastatin) arm and 49.1% in the simvastatin arm (hazard ratio 1.04; 95% CI 0.94-1.15).

Ezetimibe targets the Niemann–Pick C1–like 1 (NPC1L1) protein, thereby reducing absorption of cholesterol from the intestine. 15,16 When added to statins, ezetimibe reduces LDL cholesterol ...

Adding ezetimibe to atorvastatin significantly boosted the attainment of lipid targets as specified by both Canadian and European ... Less than 1.0 mg/L for high sensitivity-C-reactive protein ...

In this prespecified, nested analysis, investigators evaluated the role of several cardiovascular biomarkers as a possible means to identify clinical benefit with ezetimibe. The biomarkers—hs-cTnT, ...

Diabetes was linked with lower LDL and HDL cholesterol, but higher levels of triglycerides and high-sensitivity C-reactive protein (hs-CRP). LDL cholesterol decreased from admission to 1 year by 0.46 ...

Additionally, early ezetimibe was linked to fewer cardiovascular deaths at 3 years relative to late combination (HR 1.64, 95% CI 1.15-2.63) and no ezetimibe at all (HR 1.83, 95% CI 1.35-2.69).

For patients with hypercholesterolemia, simvastatin is superior to ezetimibe for producing lymphocyte-suppression and systemic anti-inflammatory and endothelial protective effects.