Mutations have conventionally been categorized as either those arising in the germline or somatic mutations acquired during life ... cause of a wide variety of human diseases (see Table S1 ...

Figure 1: Detection of somatic mutations acquired in early human embryogenesis ... wide mean WGS coverage + 1.645 × s.d.; for example, the cutoff is approximately 46× in typical 30 ...

Some gene mutations can be either hereditary or acquired. For example, most p53 gene mutations are somatic, or develop during adulthood. Much less commonly, p53 mutations can be inherited ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key ... have a role in disease progression. For example, men with inherited or acquired ...

The generation of induced pluripotent stem cells (iPSCs) from adult easily accessible somatic tissues was introduced ten years ago. This technology has revolutionized our opportunities to study human ...

Genetic mutations that are inherited from parents are known as germline mutations, but mutations can also in cells arise after birth. These so-called somatic mutations can have a variety of impacts, ...

Next, the team is working towards identifying other acquired mutations ... the Brain Somatic Mosaicism Network, the Psychiatric Genomics Consortium, the Allen Discovery Center for Human Brain ...

So long is the human genome ... that make sperm, for example, are constantly dividing to make more sperm, but the mutation rate in sperm is less than one-tenth of that somatic cells.

Researchers have documented that corals can pass mutations acquired ... for example in an egg or sperm cell. Mutations that occur in the rest of the body, in the somatic cells, were thought ...

In a discovery that challenges over a century of evolutionary conventional wisdom, corals have been shown to pass somatic mutations—changes to the DNA sequence that occur in non-reproductive ...