In hepatocytes, bile acids are secreted into bile canaliculi by bile salt export pump (BSEP), cholesterol ... up by hepatocytes enter the systemic circulation. Hepatocytes also efflux bile acids ...

Bile-acid-mediated activation of FXR-α-signalling pathways regulate the enterohepatic recycling of bile acids, protect against their accumulation in the liver and inhibit their own biosynthesis.