Using cryo-electron microscopy (cryo-EM), a team of structural ... in cancer -- working to understand their influence on DNA replication. Additionally, the scientists unexpectedly captured for ...

Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged. Cellular DNA is continuously exposed to both ...

The international team used cryo-electron microscopy to observe a helicase, an enzyme essential for DNA replication. This work reveals a mechanism far more subtle than previously imagined ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication ... Biology's Cryo-Electron Microscopy Facility ...

Using cutting edge cryo-electron microscopy, the team of scientists ... DNA helicases are essential during DNA replication because they separate double-stranded DNA into single strands, allowing ...

then imaged with a transmission electron microscope, resulting high-resolution, 3D models of biomolecules like the enzymes at work in DNA replication. “We started with a conundrum from our ...

Averaged electron microscope images of two intermediate helicase structures ... that lies at the core of the helicase enzyme. But DNA replication is a bi-directional process with two helicases moving ...

DNA replication is a tightly controlled process ... Using high-powered cryo-electron microscopes, Li, O'Donnell and their teams revealed previously unknown facets of the leading strand clamp ...

Now an electron microscope has captured the famous Watson-Crick double helix in all its glory, by imaging threads of DNA resting on a silicon bed of nails. The technique will let researchers see ...

Using cryo-electron microscopy (cryo-EM), a team of structural ... in cancer—working to understand their influence on DNA ...