The new research has also helped the scientists at Aarhus University to better understand the mechanism by which C5 is cleaved by enzymes in the absence of eculizumab. At Alexion, the atomic ...

This interpretation of the mechanism of action of eculizumab is consistent with the report of an asymptomatic patient with PNH who had more than 80 percent type III erythrocytes and a concomitant ...

AGNSS further stated that, “Eculizumab would help save lives and improve the quality of life for children (among whom the condition is particularly prevalent) and adults with atypical haemolytic ...

Owing to the mechanism of action of eculizumab, our patient was vaccinated against meningococcal infection before the initiation of eculizumab treatment. 5 Unabated complement activation due to ...

9 In contrast with the previously mentioned treatment options for patients with aHUS, this mechanism of action enables eculizumab to be considered in the treatment of individuals who have aHUS ...

Eculizumab was evaluated in PNH in three separate parent studies—a phase 2 pilot study and two phase 3 studies. All participants in these trials were allowed to continue eculizumab in follow-on ...