breast cancer resistance protein [BCRP], organic cation transporter [OCT] 2 and multidrug and toxin extrusion protein [MATE] 1). Genotype-dependent drug–drug interactions are also discussed.

Membrane drug transporters have been identified as a determinant of drug disposition in the body, potentially affecting absorption, pharmacokinetics, drug-drug interactions, and safety profiles.

the team had to first identify the drug transporters. In pharmacokinetics, the study of the absorption, distribution, metabolism, excretion, and toxicity of medication, drug transporters are ...

Chemists specializing in nanotechnology draw inspiration from nature to create molecular transporters that optimize the release of therapeutic drugs. A team of Canadian researchers from ...

This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity. The paper is published in the ...

Example 1: Cross-species comparison of drug handling of PAH excretion in the kidney transporter model Para-aminohippurate (PAH), a derivative of hippuric acid, is used to measure renal plasma flow.

located on the presynaptic membrane can transport NA into presynaptic neurons. In clinical applications, various small molecule drugs inhibit NET to increase the concentration of NA in the ...

Both influxes lead to the hepatic sinuses, where drugs may be extracted by hepatocytes, metabolized and subsequently exported from the cell. Uptake transporters of the SLC family facilitate the ...

This successfully maintains transporter expression, replicating the mechanisms of drug excretion in renal proximal tubules in vitro, mimicking the function of human epithelial tissue. "Listening ...