Tran DH, et al. De novo and salvage purine synthesis pathways across tissues and tumors. Cell. 2024;187(14):3602-3618.e20. Ali ES, Ben-Sahra I. Regulation of nucleotide metabolism in cancers and ...

Dr. Hoxhaj, with co-authors Diem Tran, Ph.D., Rushendhiran Kesavan, Ph.D., and Dohun Kim, B.S., used isotope tracing to follow the de novo and salvage purine pathways across normal mouse tissues ...

Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle ...

In the study, the team searched for a specific kind of metabolon, called a "purinosome," that was thought to carry out "de novo purine biosynthesis," the process by which new purines -- building ...