Purine nucleotides are essential ... Her findings suggest that the salvage pathway could be an access route for cancer cells to get their nucleotide supply when chemotherapeutic drugs inhibit the de ...

There is considerable evidence for a role for metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer’s disease (AD). Purine nucleotide synthesis ...

The structure of a nucleotide, consisting of a phosphate ... and tetrahydrofolate derivatives. This pathway is energy-intensive and requires multiple enzymatic steps. The de novo synthesis of purine ...