DNA interstrand cross-links (ICLs) are critical cytotoxic lesions produced by cancer chemotherapeutic agents such as the nitrogen mustards and platinum drugs; however, the exact mechanism of ICL ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

DNA naturally folds itself into cross-shaped structures called cruciforms that jut out along the sprawling length of its double helix. DNA cruciforms are abundant; scientists estimate as many as ...

Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.

Exposure to methylating agents, which are used in the lab and in chemotherapy, can cause an unexpected form of DNA damage, a new study reveals. These chemicals can methylate guanosine bases in DNA ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

More information: Sina Shadfar et al, The Redox Activity of Protein Disulphide Isomerase Functions in Non‐Homologous End‐Joining Repair to Prevent DNA Damage, Aging Cell (2025). DOI: 10.1111 ...

The DNA damage found in the new study included deletions of thousands of DNA bases, including at spots far from the edit. Some of the deletions can silence genes that should be active and activate ...

From the earliest days of the CRISPR-Cas9 era, scientists have known that the first step in how it edits genomes—snipping DNA—creates an unholy mess: Cellular repairmen frantically try to fix ...