Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology.

Researchers at University of Tsukuba, Osaka University, and Kitasato University developed a novel amide cyclodextrin (cyclic oligosaccharide) that can selectively capture phosphate ions in water.

Investigating the effects of amide-to-ester substitutions on membrane permeability of cyclic peptides. Cyclic peptides often exhibit low membrane permeability that can be significantly improved ...

Cyclic peptides have been difficult, and often impossible, to prepare using traditional synthetic methods. ... cis-Amide bonds of proline have been observed in many protein crystal structures.

Synthetic chemists can go around in circles trying to make the cyclic amides known as lactams. That’s because lactams with 4-, 5-, and 6-membered rings—known as β-, γ- and δ-lactams ...

This large group (named for a cyclic amide ring in their structure called a β-lactam ring) was founded by the well-known penicillin and also includes drugs such as amoxicillin and carbapenems.

The core chemical structure that makes up penicillins is a four-membered cyclic amide scaffold called chiral β-lactam,which is also frequently found in other types of major antibiotics like ...

Wesley Moran, an organic chemist at the University of Huddersfield, reported a misassigned seven-membered cyclic imino ether in 2015 (Org. Lett. 2015, DOI: 10.1021/acs.orglett.5b00333).

Amide Technologies, ... For the first time, customers have routine access to highly hydrophobic peptides, cyclic constructs, branched peptides, and mirror image proteins.

For instance, in contrast to penicillin, which enhances the electrophilicity of the cyclic amide through ring strain, salicylates reduce the electrophilicity of the aryl ester through an ...

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Researchers at University of Tsukuba, Osaka University, and Kitasato University developed a novel amide cyclodextrin (cyclic oligosaccharide) that can selectively capture phosphate ions in water.