Mutations in the p53 gene are reported to ... Here, we show that human coiled-coil domain containing 85B (CCDC85B) is induced by p53 and regulates β-catenin activity via interaction with the ...

Created with BioRender.com. (C) Sanger sequencing from samples at the indicated timepoints confirms the acquisition of an A to C mutation in CARD11, which results in the activating, coiled-coil domain ...

Here, we report the discovery of two secondary mutations within the kinase domain ... dimerization through interaction between the coiled-coil domain within the EML4 region of each monomer ...

The scientists found that all of the mutations caused changes in amino acids in a small segment of the CARD11 protein known as the coiled-coil domain, which is required for proper CARD11 function.