Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells.

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, ...

Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development. Journal of General Physiology, 2022; 154 (10) DOI: 10.1085/jgp.202213084; ...

Statins work by blocking a protein in the cholesterol biosynthesis pathway called HMGCR. The idea was to attack the cholesterol pathway from two angles by combining simvastatin, ...

Surprisingly, they found that one of the most affected pathways was the cholesterol synthesis pathway, mediated by a protein called SREBP2. Without PIN1, the bladder cells contained much lower ...

Aerobic exercise and a high capacity for exercise may protect against metabolic dysfunction-associated steatotic liver ...

Orphan nuclear receptors influence the onset and progression of MASLD, particularly in lipid metabolism, inflammation, ...