Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells.

Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development. Journal of General Physiology, 2022; 154 (10) DOI: 10.1085/jgp.202213084; ...

PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway. Article Publication Date. 14-Jan-2025.

Statins work by blocking a protein in the cholesterol biosynthesis pathway called HMGCR. The idea was to attack the cholesterol pathway from two angles by combining simvastatin, ...

Researchers have found a new target that may be the key to raising levels of "good" cholesterol--a hot topic in drug discovery circles. The team at Penn's School of Medicine found that a ...

Surprisingly, they found that one of the most affected pathways was the cholesterol synthesis pathway, mediated by a protein called SREBP2. Without PIN1, the bladder cells contained much lower ...

Aerobic exercise and a high capacity for exercise may protect against metabolic dysfunction-associated steatotic liver ...