Cheng et al. have now designed autophagy-inducing antibodies (AUTABs) that promote internalization and lysosomal degradation of their target cell surface receptor through autophagy. Autophagy ...

Most major biological molecules, including all proteins, DNA and RNA, point in one direction or another. In other words, they ...

Transmembrane signaling systems include membrane-bound cell surface receptors and molecules called ligands that bind to these receptors. In its most general use, "ligand" is a term for something ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

“It will be very interesting to find out if this class of molecules in the nervous system just modulates neurotransmitter receptors, or whether they regulate other cell surface receptors. We really ...

CAR T-cell therapies have demonstrated efficacy in treating blood cancers but, so far, their safety and effectiveness in ...

Basic science researchers at the Johns Hopkins University School of Medicine are advancing heart health research by finding ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

The serotonin 2A receptor, which is highly expressed in the brain cortex ... Or, “does it mean that they’re just an inactive pool waiting to get exported to the cell surface?” Olson says. These are ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...