A super-resolution microscopy technique offers an unparalleled glimpse into how monoclonal antibodies bind to their targets ...

When a signaling molecule joins with an appropriate receptor on a cell surface, this binding triggers a chain of events that not only carries the signal to the cell interior, but amplifies it as well.

Transmembrane signaling systems include membrane-bound cell surface receptors and molecules called ligands that bind to these receptors. In its most general use, "ligand" is a term for something ...

Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children's Hospital of ...

The cryo-EM images showed that the GAIN domain of the receptor assumed several different positions in relation to the cell surface. Each different position of the GAIN domain created a different ...

Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh developed a new way to profile brain cancers in children, paving ...

The randomness of this process means that these antibodies or T cell receptors aren't tailored to recognize any specific molecules on the surface of invaders. But their dizzying diversity ensures ...

ER+/PR+ breast cancer, common and hormone-responsive, offers a better prognosis and is key in treatment research advancements ...

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.