The research team hypothesized that binding of the antigen to the T-cell receptor would cause a conformational change, allowing it to initiate a downstream signaling cascade. By comparing an ...

Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth ...

Single molecule tracks of Zap70 overlaid with T cell receptor microclusters shows signal transfer at early moments of T cell activation. Disclaimer: AAAS and EurekAlert! are not responsible for ...