They also showed that a low dose of carvedilol (e.g., <25 mg per day) is as effective as higher doses (e.g., 25–50 mg per day) at decreasing HVPG, with a lower risk of causing arterial hypotension.

In the Australia‑New Zealand trial, death and total hospitalizations were reduced by about 25% over 18 ... was 7.2%. Carvedilol was titrated to a mean dose of 17.5 mg twice daily and maintained ...

Patients were switched if they were stable on a minimum dose of 25 mg b.i.d. carvedilol or 100 mg metoprolol. The crossover was performed within 1 day during monitoring of blood pressure and heart ...

Carvedilol has the capacity to block both the β-1 and β-2 adrenergic receptors, as well as the α-1 receptors. There is evidence to indicate that full adrenergic blockade by carvedilol improves ...