Deregulation of the cell cycle commonly occurs during tumour development ... The combination of indisulam with capecitabine showed additive effects in preclinical studies when both agents were ...

Our study provides proof-of-principle that cancers with specific genetic defects and dysregulated metabolic cell cycle checkpoints ... cells became sensitive to capecitabine and paclitaxel.

cell-cycle arrest, and induction of apoptosis. Background: Recent data suggest that patients with operable triple negative breast cancer (TNBC) may derive greater benefit from the addition of ...

During the first cycle of capecitabine development, three concomitant drugs were found to affect 5-FU clearance. [5] Paracetamol and morphine increased 5-FU clearance by 26% and 41%, respectively ...

population (patients who underwent random assignment), and safety was analyzed in patients who received at least one cycle of chemotherapy. This study was designed to test the superiority of the ...

We evaluated capecitabine (an oral fluoropyrimidine ... if they had a histologically proven adenocarcinoma, squamous-cell carcinoma, or undifferentiated carcinoma of the esophagus ...

CYT-0851 demonstrated activity in combination with capecitabine in heavily pretreated ... lactate that impairs glycolysis and inhibits tumor cell growth, making MCTs an attractive target for ...

Capecitabine (Xeloda, Roche ... is a water-soluble platinum-based cytotoxic drug that prevents DNA replication, and hence cell division, by cross-linking DNA. Oxaliplatin in combination with ...