In this review, we discuss the pathways of cell senescence, the mechanisms involved and the role that these pathways have in regulating the initiation and progression of cancer. Forty years ago ...

If cells undergo a senescence response ... that influence oncogene-induced senescence play a role in the risk of cancer? The dysplastic nevus syndrome caused by the germ-line INK4A Leiden mutation ...

Cellular senescence is a mechanism of cellular aging that has diverse effects on both cancer and tissue aging. After a certain number of divisions, primary human cells permanently lose the ability to ...

"Senescence is a double-edge sword," says Dr. Lowe, a co-responding author on a new paper published June 17 in Nature. "Cells in this state play an important role in wound healing and cancer ...

from mechanisms to therapeutic opportunities," Nat Rev Mol Cell Biol, 22(2):75-95, 2021. 12. J. Yang et al., "The paradoxical role of cellular senescence in cancer," Front Cell Devl Biol, 9, 2021. 13.

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed by a team from Osaka Metropolitan ...

This process, known as cellular senescence, serves as a defense mechanism against cancer. However, as senescent cells accumulate with age, they begin to negatively impact tissues through the SASP ...

In “Senescence, NK cells, and cancer: navigating the crossroads of aging and disease,” Celularity scientists discuss how aging may influence the battle between the immune system and cancer ...

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight. Kamal is a freelance science journalist based in the UK with a PhD in virology ...

This discovery has been detailed in their publication in the journal Research, titled "MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer." MAVS is an antiviral signaling ...