If cells undergo a senescence response ... that influence oncogene-induced senescence play a role in the risk of cancer? The dysplastic nevus syndrome caused by the germ-line INK4A Leiden mutation ...

Senescence is an irreversible growth arrest phenotype adopted by cells that has a key role in protecting organisms from cancer. There is now considerable interest in therapeutic strategies that ...

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed by a team from Osaka Metropolitan ...

Their study showed that cancer stem cells induce senescence in macrophages. The findings are published in the Journal for ImmunoTherapy of Cancer in an article titled, “Tumor cell-induced ...

from mechanisms to therapeutic opportunities," Nat Rev Mol Cell Biol, 22(2):75-95, 2021. 12. J. Yang et al., "The paradoxical role of cellular senescence in cancer," Front Cell Devl Biol, 9, 2021. 13.

Although senescence can be a good thing; like when genetic mutations arise that can lead to cancer, senescence can stop uncontrolled cell growth and prevent tumors from developing. However, when there ...

In “Senescence, NK cells, and cancer: navigating the crossroads of aging and disease,” Celularity scientists discuss how aging may influence the battle between the immune system and cancer ...

Chemotherapy is a powerful weapon against cancer, but certain cells resist treatment by entering a dormant stage called senescence. These therapy-induced senescent (TIS) cells may become resistant to ...

where senescent macrophages accumulated in aging tissue and in early stages of non-small-cell lung cancer (NSCLC) driven by the Kras oncogene. “We found that the macrophages were present in the ...