Fifty years ago, Bernard Katz's seminal work revealed that calcium triggers neurotransmitter release by stimulating ultrafast synaptic vesicle fusion. But how a presynaptic terminal achieves the ...

Brain ion channels have molecular memory, changing shape after repeated signals, affecting neurotransmitter release.

A new study conducted by researchers at the Max Planck Florida Institute for Neuroscience uncovers critical aspects of calcium channel ... variability in neurotransmitter release during neuronal ...

as a calcium store. This leads to elevated neurotransmitter release and, ultimately, to fatal neuronal hyperexcitability. These fundamentally new findings have now been published in the ...

Calcium ions rapidly stream into the presynaptic ... with neurotransmitter to fuse with the plasma membrane and release the neurotransmitters into the synaptic cleft. Speed is essential in ...

"We have, for the first time, identified the calcium sensor that triggers neurotransmitter release at an inhibitory synapse," summarizes Peter Jonas. Interneurons that use GABA as neurotransmitter ...

They discovered that, without Rap1, the L-type calcium channels were more active and more abundant at synapses all the time, increasing the release of neurotransmitters. The results showed that ...

The team then used imaging techniques to measure acetylcholine levels and calcium influx. Calcium is essential for neurotransmitter release. In the eIF4E mice, acetylcholine binding to dopamine axons ...

Nerve transmission: Calcium ions are involved in transmitting nerve impulses throughout the body. They help regulate the release of neurotransmitters and facilitate communication between nerve cells.

Under normal conditions, brain tissue is sufficiently supplied with energy, which is in part required for the selective release and reuptake of neurotransmitters. "However, if there is no longer ...