Two research teams led by Warner Greene at the Gladstone Institutes in San Francisco have demonstrated that the vast majority of CD4 T cells in lymphoid tissues, despite their ability to resist full ...

Ongoing research investigating how HIV remains as a latent reservoir in resting T helper cells to ensure viral persistence in patients that have undergone treatment with highly active antiretroviral ...

Their investigation also identified persistent T cells with HIV even after 10 and 29 days of antiretroviral therapies. The findings suggest new therapies that target the reservoir of dormant HIV ...

CD4-positive T cells are a subtype ... A key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T cell. Hypothalamus participates in systemic ...

I am investigating the mechanisms of how reservoirs are formed and potential ways to remove the latent reservoir. My latest work involves investigating the roles of endothelial cells in HIV infection ...

Immunocore’s big swing for a functional HIV cure has cleared its first hurdle. No serious adverse events were tied to the British biotech’s bispecific T-cell engager in a phase 1/2 trial, and ...

INSTIs block integrase, an enzyme that HIV uses to put HIV DNA into human DNA inside the CD4 T cells. INSTIs belong to a category of drugs known as integrase inhibitors. INSTIs are well ...

The median for all nine patients decreased from 191 copies / million CD4+ T cells to 116 copies / million ... patients and a first reduction in the HIV reservoir in the blood of chronically ...

Metformin, a drug used to treat type 2 diabetes, could help deplete the viral reservoir ... of metformin on HIV replication ...

More information: Costin Tomescu et al, Gene-modified NK cells expressing CD64 and preloaded with HIV-specific BNAbs target autologous HIV-1–infected CD4+ T cells by ADCC, The Journal of ...

"They're safe and seem to be working to reduce the size of the reservoir through ... and average CD4 count at enrollment was 800 cells/µL. Most had HIV clade B (80%), and 6% had clade A.