The team next focused on the species Pristionchus pacificus which showed many variations in the number of TGF-ß genes compared to other nematodes including C. elegans. By making mutations in numerous ...

The details of the signaling pathways regulating the differentiation of the cells are well studied in C. elegans, but up to now there was no indication for the common origin of dauer larvae and ...

Figure 1: The dauer pheromone ascarosides and the modular structure of the ascaroside family of pheromones. Figure 2: Role of insulin/IGF-1 and TGF-β pathways in controlling reproductive growth ...

The ligand DAF-7, secreted from ASI neurons, acts on its receptor DAF-1 located on RIM neurons to activate the downstream TGF-β Dauer signaling pathway, thereby inducing UPR mt in intestinal cells.

A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans, Scientific Reports (2016). DOI: 10.1038/srep38764 Journal information: Scientific Reports ...

The relevance of DAF-2 to C. elegans physiology was initially based on its association with a stage of diapause arrest called "dauer." Entry into this developmental stage, characterized by ...

HOUSTON – (April 4, 2006) – When the nematode Caenorhabditis elegans has enough to eat, enjoys the right temperatures and is not crowded out by its fellows, it produces a hormone, which binds ...

Increased collagen expression is a common feature of many different pathways to extended longevity in worms. ... The paper C.Y. Ewald et al., “Dauer-independent insulin/IGF-1-signalling implicates ...

First author and researcher at the Schroeder Lab Jingfang Yu, grad noted that there was still serotonin production in the mutated worm C. elegans that lacked TPH-1. “We would think that if we ...

Researchers have provided experimental proof of a pathway that controls aging, ... Tc1, Tc3, and both - extended lifespan in C. elegans. Sturm et al./Deep Biotech Solutions.