Scientists have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. The increase in lifespan ...

Figure 2: Role of insulin/IGF-1 and TGF-β pathways in controlling reproductive growth versus dauer development ... Figure 5: Structures of the C. elegans acyl-CoA oxidases ACOX-1.1 and ACOX ...

Mutation in mitochondrial gene doubles the lifespan in the worm C. elegans by turning on a detox pathway, researchers report. A mutant worm with a change in one mitochondrial gene produces more ...

"Our evidence suggests that DAF-36 works early in a pathway ... the C. elegans reproductive capacity and prevent the organism from going into the immature long-lived larval phase called dauer ...

Additionally, all components of the TGF-β Dauer signaling pathway are required ... further examined the physiological phenotypes of C. elegans with neuronal mitochondrial stress and observed ...

An international team increased the life of a nematode worm known as C. elegans by genetically altering two "cellular pathways"—biological signalling systems which cells use to communicate with ...

By comparison, restoration of DAF-2 or AGE-1 in muscle regulated metabolism but did not reverse the dauer stage or lifespan ... essential functions in C. elegans, and the metabolic and ...

This worm, the C. elegans, is often used in aging research. Even though it’s biologically a long way from humans, it shares many genetic pathways with humans. “Nature doesn't waste basic cell ...

Past research had found a link between two signaling pathways in C. elegans — the insulin signaling pathway and the target of rapamycin pathway — and aging. Specifically, scientists found that ...

In experiments with roundworms of the species Caenorhabditis elegans, researchers at the State University of Campinas (UNICAMP) in Brazil found that when this communication pathway is dysregulated ...

The study, “Parallel Pathways for Serotonin Biosynthesis and Metabolism in C. elegans,” challenges the existing knowledge of how serotonin is produced and what happens to the neurotransmitter ...