Oncotarget published "Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients" which reported that the association between genetic ...

If you have breast cancer, chances are it’s not caused by a faulty gene you were born with. Most of the time, genes that lead to the disease mutate sometime during your life and aren’t an ...

Some specific germline and somatic gene mutations may increase a person’s risk of developing breast cancer that progresses to MBC. For example, several germline mutations, such as BRCA1 and ...

"While a few examples of genes responsible for changing patterns of somatic mutations were known before, such as the BRCA genes that predispose to breast and ovarian cancer, and the Lynch syndrome ...

Hereditary genetic mutations are a key cause of cancer. One recent study estimated that about 17% of patients with cancer harbor inherited defects in key cancer genes. But it is not well understood ...

Take BRCA1 and BRCA2, two well-known genes that confer a high risk of breast cancer when they contain mutations. There are 125,950 base pairs in the BRCA 1 mutation, noted Brawley. “Think of it ...

Key Takeaways. Hereditary breast cancer results from inherited mutations, primarily in BRCA1 and BRCA2, increasing lifetime cancer risk. Additional genes like TP53, PTEN, PALB2, CHEK2, and ATM ...

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more ...

Men, of course, can get breast cancer too, but it's rare, even among BRCA-mutation carriers. Read: Cancer supertests are here. The full significance of the link between BRCA mutations and ...