DEAR MAYO CLINIC: I was recently prescribed high blood pressure medication. My routine was to take the pills before bed, but I’m finding when I do, I’m up all night using the bathroom.

≥160mm Hg and diastolic blood pressure (DBP) ≤95mm Hg were randomised to receive amlodipine 5 mg/day or hydrochlorothiazide 50 mg/day for 8 weeks (phase II). After 4 weeks of active treatment ...

If participants failed to achieve the target BP by the end of treatment period 2, hydrochlorothiazide ... of medications to lower BP at the initial visit as well as a blood pressure of >140/ ...