In mitosis, ZM447439 and Hesperadin both inhibit chromosome alignment and spindle-checkpoint function. RNAi-based experiments and overexpression of Aurora-kinase mutants indicate that these ...

Experts in mitosis (cell division) have made discoveries that explain how one protein -- the kinase Aurora B -- could have such a large role in guiding and policing the process of cell division.

B and C members and are involved in the regulation of cell division and mitosis. Aurora A overexpression correlates with poor prognosis and is considered a therapeutic target for cancer treatments, ...

Researchers recently exploited the fact that XIST temporarily dissociates from the X chromosome during mitosis and find that Aurora B kinase helps regulate the RNA's chromatin binding. Early in ...

Lung metastasis targeting by a tumor-killing Salmonella typhimurium mutant. Background: Aurora B kinase is involved in coordinating multiple steps of mitosis, including chromosome condensation, ...

AURKA inhibitors might enhance outcomes of metastatic prostate cancer treated with androgen receptor pathway inhibitors by intensifying androgen receptor inhibition, increasing DNA-damage-related cell ...

The company is also developing selective degraders of Aurora A kinase for treating aggressive pediatric cancers, illustrating a multifaceted approach to combating difficult-to-treat malignancies.

Danusertib (PHA-739358) is a small-molecule pan-aurora kinase inhibitor. This phase I dose escalation ... Because aurora kinases are largely involved in cell cycle progression and mitosis, which is ...

Alisertib is an adenosine triphosphate–competitive and reversible inhibitor of aurora kinase A and results in disruption of mitosis leading to apoptosis of rapidly proliferating tumor cells that ...