In mitosis, ZM447439 and Hesperadin both inhibit chromosome alignment and spindle-checkpoint function. RNAi-based experiments and overexpression of Aurora-kinase mutants indicate that these ...

B and C members and are involved in the regulation of cell division and mitosis. Aurora A overexpression correlates with poor prognosis and is considered a therapeutic target for cancer treatments, ...

Researchers recently exploited the fact that XIST temporarily dissociates from the X chromosome during mitosis and find that Aurora B kinase helps regulate the RNA's chromatin binding. Early in ...

Danusertib (PHA-739358) is a small-molecule pan-aurora kinase inhibitor. This phase I dose escalation ... Because aurora kinases are largely involved in cell cycle progression and mitosis, which is ...

Lung metastasis targeting by a tumor-killing Salmonella typhimurium mutant. Background: Aurora B kinase is involved in coordinating multiple steps of mitosis, including chromosome condensation, ...

AURKA inhibitors might enhance outcomes of metastatic prostate cancer treated with androgen receptor pathway inhibitors by intensifying androgen receptor inhibition, increasing DNA-damage-related cell ...

Alisertib is an adenosine triphosphate–competitive and reversible inhibitor of aurora kinase A and results in disruption of mitosis leading to apoptosis of rapidly proliferating tumor cells that ...

The company is also developing selective degraders of Aurora A kinase for treating aggressive pediatric cancers, illustrating a multifaceted approach to combating difficult-to-treat malignancies.

MLN8237 is an oral, selective Aurora A kinase inhibitor discovered and developed by Millennium scientists. “We are very excited to begin these studies examining MLN8237 in several hematologic ...

Our previous work led to identification of Smad proteins as substrates for Mps1 in mitosis (Zhu et al. 2007). Recently we solved the crystal structure of the Mps1 kinase domain in collaboration with ...