As Aurora-A kinase controls mitosis by regulating cyclin B localization/stability 39, 40 and bipolar spindle assembly, 38 we checked for mitotic abnormalities upon USP7 depletion.

We show that the mitotic kinase Aurora-A directly interacts with and phosphorylates RASSF1 and that RASSF1A is phosphorylated by Aurora-A during mitosis.

Aurora kinases, a group of serine/threonine protein family, comprise Aurora A, B and C members and are involved in the regulation of cell division and mitosis. Aurora A overexpression correlates with ...

Experts in mitosis (cell division) at the University of Virginia Health System have made discoveries that explain how one protein – the kinase Aurora B – could have such a large role in ...

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they ...

Nurix Therapeutics Showcases Promising Preclinical Data for BTK, BRAF, and Aurora A Kinase Degraders at AACR 2025 Annual Meeting ...

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they ...

The drug, alisertib or MLN8237, inhibits the enzyme aurora A kinase, which is known to be very active during cell division. The present study, published in the journal Investigational New Drugs ...

The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of the Journal of Cell Biology.

Alisertib is a highly selective small molecule inhibitor of Aurora A kinase which may result in disruption of the assembly of the mitotic spindle apparatus and cell proliferation inhibition. At ...

Aurora kinases (AURKA, AURKB and AURKC) are a family of serine/threonine kinases involved in multiple facets of mitosis. These are aberrantly up-regulated in several cancers, suggesting that they ...