We show that the mitotic kinase Aurora-A directly interacts with and phosphorylates RASSF1 and that RASSF1A is phosphorylated by Aurora-A during mitosis.

Aurora kinases, a group of serine/threonine protein family, comprise Aurora A, B and C members and are involved in the regulation of cell division and mitosis. Aurora A overexpression correlates with ...

In contrast, during the first mitosis in C. elegans, aurora-A is not required for centrosome separation (Schumacher et al., 1998), although in the absence of the kinase bipolar mitotic spindles ...

Experts in mitosis (cell division) have made discoveries that explain how one protein -- the kinase Aurora B -- could have such a large role in guiding and policing the process of cell division.

Aurora Kinase inhibitors The dawn of a new approach to cancer. Cell cycle inhibitors represent a key approach to the treatment of cancer. Therapeutic agents have traditionally targeted early stages of ...

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they ...

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they ...

Background: Aurora B kinase is involved in coordinating multiple steps of mitosis, including chromosome condensation, chromosome segregation and cytokinesis. These essential functions of Aurora B and ...

Aurora kinases are serine/threonine kinases with a key role in mitosis. The aurora kinase family consists of three members, auroras A, B, and C. Aurora A is localized to the centrosomes of interphase ...

angiogenesis inhibitor, ENMD-981693. In preclinical studies, ENMD-981693 has been shown to inhibit a unique profile of angiogenic tyrosine kinase targets in addition to the Aurora kinases ...

Nurix Therapeutics Showcases Promising Preclinical Data for BTK, BRAF, and Aurora A Kinase Degraders at AACR 2025 Annual Meeting April 25, 2025 — 01:12 pm EDT.

Three Aurora kinases (AURKA, AURKB and AURKC) are required for cell division and their activities/expression is increased in many human cancers. Accordingly, AURK inhibitors have entered early ...