that disrupts its kinase activity failed to fully activate YAP activity in the reporter system (Figure 3g). These results suggest that Aurora A signaling can positively regulate YAP-directed gene ...

AURKA inhibitors might enhance outcomes of metastatic prostate cancer treated with androgen receptor pathway inhibitors by intensifying androgen receptor inhibition, increasing DNA-damage-related cell ...

PHILADELPHIA – In preclinical models, combining an investigational Aurora Kinase A (AURKA ... protein downstream of KRAS that amplifies RAS signaling and is also involved in regulating cell ...

About Aurora A Kinase Aurora A kinase (AURKA ... includes degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene ...

Aurora A overexpression correlates with poor prognosis and is considered a therapeutic target for cancer treatments, although the clinical development of Aurora kinase inhibitors has been so far ...

Aurora kinases (AURKA, AURKB and AURKC ... Methods: We did immunohistochemistry using a monoclonal AURKB antibody (Cell Signaling Technology, Beverly MA; 1:50 dilution). In vitro cell survival and ...

Lung metastasis targeting by a tumor-killing Salmonella typhimurium mutant. Background: Aurora B kinase is involved in coordinating multiple steps of mitosis, including chromosome condensation, ...