Distinct pharmacologic profiles, especially actions on 5-hydroxytryptamine (5-HT) receptor subtypes, may contribute to the advantage of atypical antipsychotics in terms of adverse effects.

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily ... to selectively modulate muscarinic receptors by targeting the acetylcholine binding ...

Supporting the relevance of studying hallucinogens to understand schizophrenia, however, is the observation that the serotonin 2A receptor also interacts with atypical antipsychotic medications ...