Pharmacodynamics includes interactions of a drug with receptors, transporters and downstream targets. Although the primary mechanism of action for antidepressants is thought to involve ...

MAOI mechanism of action This group of drugs works on the brain differently than the other types of antidepressants. You have an enzyme called monoamine oxidase in your brain. Its job is to remove ...

Put simply, we know these drugs work ... actions that may contribute to its antidepressant effect, but no clear specific mechanism of action. It appears to be a mild monoamine oxidase inhibitor ...

Auvelity, from Axsome Therapeutics, marks the first drug with a different mechanism of action approved for treating depression in 60 years. In clinical trials, participants reported progress ...

The KOR/dynorphin system has been known to modulate depression, anhedonia, and anxiety. It has a novel mechanism ... of action. According to KOLs interviewed by the company, the drug also has ...

Since the 1980s, selective serotonin reuptake inhibitor (SSRI) antidepressants have been ... prescriptions in the UK alone. Yet their mechanisms of action—and their wider effects across the ...

Research in animals has shown that the diabetes drug dulaglutide ... may reduce symptoms of depression. A new study published in Brain and Behavior reveals the mechanisms that are likely involved.

of ketamine’s mechanism of action, she says: “ ‘Why’ is not trivial.” John Krystal of Yale University, whose work first showed the antidepressant effects of the drug and who was not ...

Thus, drugs targeting homeostatic mechanisms may preserve memory ... plasticity that they find is necessary for the rapid antidepressant action of ketamine. Although most drugs do have side ...

It is the first drug to treat major depressive disorder that works within a week of taking it and is the first new pill to treat depression using a new mechanism of action in more than 60 years ...

The drug's true identity emerged after ... described tianeptine as "an antidepressant, the exact mechanism of action of which is not known." Both tricyclics and SSRIs work by targeting receptors ...