Pharmacodynamics includes interactions of a drug with receptors, transporters and downstream targets. Although the primary mechanism of action for antidepressants is thought to involve ...

MAOI mechanism of action This group of drugs works on the brain differently than the other types of antidepressants. You have an enzyme called monoamine oxidase in your brain. Its job is to remove ...

Since the 1980s, selective serotonin reuptake inhibitor (SSRI) antidepressants have been ... prescriptions in the UK alone. Yet their mechanisms of action—and their wider effects across the ...

Mechanisms of Q-Tc Interval Prolongation with Antidepressants and Antipsychotics ... disruption of hERG potassium channels. Though these drugs had little direct effect on cardiac ion channels ...

The KOR/dynorphin system has been known to modulate depression, anhedonia, and anxiety. It has a novel mechanism ... of action. According to KOLs interviewed by the company, the drug also has ...

Thus, drugs targeting homeostatic mechanisms may preserve memory ... plasticity that they find is necessary for the rapid antidepressant action of ketamine. Although most drugs do have side ...

Auvelity, from Axsome Therapeutics, marks the first drug with a different mechanism of action approved for treating depression in 60 years. In clinical trials, participants reported progress ...

of ketamine’s mechanism of action, she says: “ ‘Why’ is not trivial.” John Krystal of Yale University, whose work first showed the antidepressant effects of the drug and who was not ...

Research in animals has shown that the diabetes drug dulaglutide ... may reduce symptoms of depression. A new study published in Brain and Behavior reveals the mechanisms that are likely involved.

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...