Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s,” Charles Piller looks how the amyloid hypothesis took over ...

The beta amyloid peptide (Abeta) is the primary component of the ... We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

Amyloid-beta is a protein fragment naturally produced ... Alzheimer’s begins when Aβ42 molecules stick together to form clumps called oligomers. These oligomers aggregate into amyloid plaques ...

Explore the potential of monoclonal antibodies in Alzheimer’s treatment, including breakthroughs and challenges in this ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that ...

This allows copper and zinc to react with Aβ released into the synaptic cleft to form oxidized, cross-linked soluble oligomers and precipitated amyloid. While the soluble Aβ monomers are ...

generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that ...

The factor that tips you over the edge from being at risk for a disease to actually developing the disease is not always ...

Amyloid-beta: As Alzheimer’s disease develops ... The scientists focused on the “building blocks” of NFTs, including ...