The beta amyloid peptide (Abeta) is the primary component of the ... We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

Ever since Alois Alzheimer first described the neurological changes that characterize the disease that now bears his name, amyloid plaques ... s targeting of Aβ oligomers, has opened the ...

Explore the potential of monoclonal antibodies in Alzheimer’s treatment, including breakthroughs and challenges in this ...

Scientists have identified a biomarker for Alzheimer's that may help doctors spot the early signs of protein buildup in the ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that ...

generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques ...

Piller is an investigative journalist for Science. In November 2022, Dennis Selkoe, a Harvard professor of neurologic diseases and among the most celebrated and prolific Alzheimer’s researchers ...

This allows copper and zinc to react with Aβ released into the synaptic cleft to form oxidized, cross-linked soluble oligomers and precipitated amyloid. While the soluble Aβ monomers are ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that ...

The factor that tips you over the edge from being at risk for a disease to actually developing the disease is not always ...

With UdeM professor Jonathan Brouillette, Mongrain said she's "looking to identify biomarkers present at the onset of ...