Quality by design As amorphous solid dispersions are often formulated for Biopharmaceutics Classification System (BCS) Class II and Class IV APIs, the critical quality attributes (CQAs) for a product ...

“Co-amorphous systems are reported to combine the advantages of a co-crystal and solid dispersion system with fewer disadvantages,” Foster remarks. “The use of co-amorphous systems is a relatively new ...

The Process H sample (Figure 2e) shows irregularly shaped particles (partially-amorphous solid dispersion) ranging in size from sub-μm to ~2 μm. Figure 3. a-b: Raman images ...

“With our new hot melt extrusion technology, Aenova is expanding its range of innovative platforms to provide modern, ...

The Formulation Science and Technology (FST) Interest Group of the Royal Society of Chemistry is pleased to announce the ‘Innovations in the formulation of Amorphous Solid Dispersions 2023’. This will ...

In a paper recently published in the Journal of Pharmaceutical Sciences, researchers reported a method to determine the miscibility of amorphous solid dispersions (ASDs) based on the overlap ...

Rational design of amorphous solid dispersion. In order to stabilize the amorphous state of the drug and inhibit the crystallization of the amorphous drug in its solid or aqueous state, excipients are ...

Recent work by a team of researchers at Queen’s University Belfast and University College London has reported on a newly developed strategy for the manufacture of a high drug loaded amorphous solid ...

Unlike crystalline solids, where atoms line up in an orderly grid, amorphous materials are a molecular jumble. This disorder can boost solubility dramatically, but it comes at a cost: instability.