The three main complications of long-term amiodarone use are pulmonary toxicity, thyroid disease and liver toxicity. Pulmonary toxicity progresses slowly in the setting of amiodarone use ...

Amiodarone is a lipophilic drug that concentrates in the liver and usually, over a period of time, leads to toxicity related to drug accumulation. There is marked histological similarity between ...

Although long-term oral amiodarone therapy does not increase mortality and may improve mortality in some patients, noncardiac toxicity is a major problem. In randomized trials, 41% of patients ...