Progressive muscular atrophy (PMA) is clinically characterized solely by signs of lower motor neuron dysfunction, so patients with this condition are commonly excluded from ALS clinical trials.

ALS affects both the upper motor neurones that travel from the brain to the spinal cord and the lower motor neurones, which branch out to the various muscle groups around the body.

Areflexic, or flaccid, bladder and bowels occur when the spinal cord injury is low enough to damage the cauda equina and alpha motor neurons. It also occurs in all spinal cord injury patients during ...

Multiple models have been proposed for the mechanism by which mutant superoxide dismutase 1 induces motor neuron death and amyotrophic lateral sclerosis. A combination of cell biology and genetics ...

For the best experience, please enable JavaScript in your browser settings. According to Dr Matilda Wendo, a Neurologist at The Aga Khan Hospital, MNDs are a group of ...

Footballer Ezekiel Otuoma and his wife Rachael Otuoma. Otuoma died after a long battle with Motor Neurone Disease (MND). [File, Standard] Former AFC Leopards winger Ezekiel Otuoma passed away at ...