This fixed-dose combination product combines lesinurad, a uric acid transporter 1 (URAT1) inhibitor, with allopurinol, a xanthine oxidase inhibitor in one tablet. Allopurinol reduces the ...

The fixed-dose product combines lesinurad, a uric acid transporter 1 (URAT1) inhibitor, with allopurinol, a xanthine oxidase inhibitor in one tablet. Allopurinol reduces the production of uric ...

Gout Treatment . Allopurinol is a xanthine oxidase inhibitor and acts by reducing serum uric acid levels and oxidative stress. Treatment is generally well tolerated, Mackenzie noted in her ...

High-dose allopurinol caused regression of left ventricular hypertrophy in patients with chronic kidney disease; allopurinol also improved endothelial function over 9 months of treatment.

Xanthine Oxidase Inhibitors: Allopurinol is a purine analog that reduces uric acid production by inhibiting xanthine oxidase and is considered first-line therapy for most gout patients. 20 Serum ...

Muir et al. investigated the effects of the xanthine oxidase inhibitor allopurinol on levels of uric acid and the proinflammatory marker ICAM1 (intercellular adhesion molecule 1) after acute ...

An investigational non-purine xanthine oxidase inhibitor for gout treatment, called tigulixostat, appeared effective enough in a phase II trial that a pivotal study is now getting underway.

Antibiotic Prophylaxis Cuts Recurrent UTI Risk by 50% Benefit of adding the uricosuric drug to a xanthine oxidase inhibitor persists for up to 2 years, extension study shows. Combination therapy ...

ROCKVILLE, Md. and SUZHOU, China, Dec. 14, 2022 /PRNewswire/ -- Innovent Biologics ("Innovent", HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes ...