A phase 2 trial found that adding bevacizumab to alectinib significantly delayed disease progression, protected against brain ...

Perspective from These results highlight the role the ALK pathway plays in these rare diseases. Patients with ALK-driven anaplastic large cell lymphoma and inflammatory myofibroblastic tumors have ...

It is challenging to balance physician autonomy with rigid clinical pathways when it comes to these institutional decisions, which often are made by a small group. The management of ALK-positive ...

Setting Quality Improvement Priorities for Women Receiving Systemic Therapy for Early-Stage Breast Cancer by Using Population-Level Administrative Data The robust and sustained clinical responses to ...

Additionally, while the estrogen signaling pathway was found to be overexpressed ... Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations, Cancer Research (2024).

If validated, the use of anaplastic lymphoma kinase (ALK) inhibitors may be a new treatment ... and animal models to evaluate protein-signaling pathways and genetic abnormalities with the goal ...

The mutations led to diseased cells. Finally, the researchers tested JAK/STAT3 pathway inhibitors in mice implanted with tumors derived from patients with ALK-negative ALCL. Tumor growth was ...

Moreover, pharmacological or genetic inhibition of the ALK-STING pathway confers protection against lethal endotoxemia and sepsis in mice. The ALK pathway is up-regulated in patients with sepsis.