As skin-care ingredients go, adapalene (like the popular over-the-counter option Differin) and its prescription cousin tretinoin have a lot in common. Both are retinoids—vitamin A derivatives ...

After years of being on adapalene (a prescription retinol cream) and getting along well with it, in 2023 I made the switch to tretinoin. The latter is considered one of the strongest retinoids ...

What is Differin? Differin is an acne-fighting gel that contains 0.1% adapalene — a powerful, prescription-strength retinoid that targets blackheads and whiteheads and prevents future blemishes.

Adapalene 0.1%; alcohol-free. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes.

Adapalene 0.3%, benzoyl peroxide 2.5%; gel. Adapalene binds to specific retinoic acid nuclear receptors. Studies have demonstrated that adapalene is a modulator of cellular differentiation ...