Clinical decision-making is often complicated when dilemmas in therapy occur. This month's column will focus on two therapeutic dilemmas. The first dilemma is whether it is safe to use an ...

Thus, ACE inhibitors appear not to mediate angioedema through an allergic or idiosyncratic reaction; rather, they seem to facilitate angioedema in predisposed individuals. Despite the ...

as “the putative mediator of angioedema induced by ACE inhibitors”. LCZ696 was designed to overcome the problem of angioedema. “Drugs that concurrently inhibit neprilysin and block ...