DUBAI, United Arab Emirates (AP) — Israel launched an expanded assault on Iran on Sunday, with direct strikes targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of missiles blamed for the deaths of four people and injuries of many others.

At least 13 Israelis have now died in the hostilities between the Jewish state and Iran that began last week. Iranian strikes carried out overnight against Israel took at least 10 lives, according to Israel’s Magen David Adom rescue service.

Iranian news media and residents of Tehran say the damage from the latest Israeli strikes appears to be significant, with several apartment buildings badly damaged. Residents say they are hearing ambulance sirens and fire trucks racing to the scenes and rescue workers are working to find casualties in the rubble.

Iran's Supreme Leader Ali Khamenei reportedly seeks refuge in a Tehran bunker as Israel launched strikes. Following a Mashhad strike, sources indicate Israel spared Khamenei to give him a "final chance" to dismantle Iran's uranium enrichment program.

Smoke and flames filled the sky over Tehran as Israel struck oil and gas facilities in the Iranian capital and targeted more nuclear facilities during attacks that carried on into Sunday after starting two days earlier.

The two powers have been exchanging barrages since Israel attacked Iran and killed many of the country’s top military leaders and scientists.

The Washington-based group Human Rights Activists reported a far higher death toll in Iran from Israeli strikes, saying the attacks have killed at least 406 people and wounded another 654. In recent crises, Iran routinely has undercounted casualties, including in the 2022 mass demonstrations over mandatory hijab laws after the death of Mahsa Amini.

Israel's military said the air force had concluded a wave of overnight strikes targeting air defenses in the area of Tehran. "We damaged—and will continue to damage—strategic sites and enemy sources of knowledge,