The Chicago Cubs will try to avoid a two-game sweep in the opening series of the MLB season on Wednesday. First pitch against the Los Angeles Dodgers will be at 6:10 a.m. ET. The defending World Series champions won the 2025 opener on Tuesday, 4-1.

The Los Angeles Dodgers will seek to take the second of two games from the Chicago Cubs to open the MLB season on Wednesday. First pitch is scheduled for 3:10 a.m. PT. Los Angeles won the first matchup on Tuesday, 4-1.

The Chicago Cubs took on on the Los Angeles Dodgers in Tokyo early Tuesday morning in the first of a two-game set to kick off the regular season, a game which ended in a 4-1 loss for the Cubs. Though Chicago struck first in the bottom of the second inning with a huge double from Miguel Amaya to bring Dansby Swanson to the plate,