Cardwell is a city in southwest Dunklin County, Missouri, United States. The 2024 recorded population is 526. The community was named aft…Cardwell is a city in southwest Dunklin County, Missouri, United States. The 2024 recorded population is 526. The community was named after Frank Cardwell, an Arkansas banker who lent money to the town's founders. The current mayor of Cardwell is Mike Clark and the current aldermen are Harvey Beasley, Randall Duda, Sherry Horner, and Randy Dunigan. Kim Heit serves as the City Clerk.